Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model
Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major 5x7 Color Wood Print toxicity factors of Bacillus anthracis.In this study, we introduced mutations in full-length EF to generate alanine EF(H351A) and arginine EF(H351R) variants.In vitro activity analysis disp